With a distinct aroma and irresistible flavor, it has commanded the attention of the world. The coffee trade is immense, second only to that of oil in its value. The history of coffee is filled with stories of those who sought to control that trade, who exacted high tariffs on coffee roasters and those who found ways to circumvent those controls.

Wednesday, April 04, 2018

Coffee and analgesic effects

The caffeine content of a cup of coffee varies enormously, but a typical 150 ml cup of instant coffee provides about 65 mg of caffeine. A chronic intake of large doses of caffeine can lead to the physical dependence, tolerance and many side effects.

Caffeine has a vasoconstricting effect on the brain and a vasodilating effect on peripheral blood flow. This property explains the presence of caffeine in several medications for migraine headaches. Caffeine produces analgesic effects on the central nervous system and enhances motoneuronal excitability, facilitating motor unit recruitment.

Caffeine has been used for a long time as an adjuvant to analgesic preparations containing aspirin, phenacetin, paracetamol, and salicyla- mide.
Coffee and analgesic effects
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